Dr. Tsutsumi Víctor


  • Pérez-Vargas JE, Zarco N, Vergara P, Shibayama M, Segovia J, Tsutsumi V, Muriel P. l-Theanine prevents carbon tetrachloride-induced liver fibrosis via inhibition of nuclear factor ?B and down-regulation of transforming growth factor ß and connective tissue growth factor. Hum Exp Toxicol. 2015 Apr 7. pii: 0960327115578864.


  • Kashina S, Flores L, Zaina S, Balleza M, Barbosa G, Tsutsumi V, Sabanero M. Activity of extracts from submerged cutured mycelium of winter mushroom Flammulina velutipes (Agaricomyctes), on the immune sustem in vitro. Int J Med Mushrooms. 2016. 18 (1): 49-57.

  • Nakamura T, Koga H, Iwamoto H, Tsutsumi V, Imamura Y, Naitou M, Masuda A, Yulkezono, Abe M, Wada F, Sakaue T, Ueno T, Li M, Alev C, Kawamoto A, Asahara T, Torimura T. Ex vivo espansion of circulating CD34+ cells enhances the regenerative effect on rat liver cirrosis. 2016. Molecuar Therapy- Methods & Clinical Development, 3, 16025.

  • Sánchez V, Serrano-Luna J, Ramírez-Moreno E, Tsutsumi V, Shibayama M. Entamoeba histolytica: Overexpression of the gal/galnac lectin, ehcp2 and ehcp5 genes in an un vivo model of amebiasis. Parasitol Int. 2016 Dec;65(6 Pt A):665-667. doi: 10.1016/j.parint.2016.08.009.


  • Hernández-Aquino E, Casas-Grajales S, Ramos-Tovar E, Flores-Beltrán RE, Arauz J, Shibayama M, Favari L, Tsutsumi V, Segovia J, Muriel P. Naringenin prevents experimental liver fibrosis by blocking TGFß-Smad3 and JNK-Smad3 pathways. World J Gastroenterol. 2017 Jun 28;23(24):4354-4368. doi: 10.3748/wjg.v23.i24.4354.

  • Casas-Grajales S, Vázquez-Flores LF, Ramos-Tovar E, Hernández-Aquino E, Flores-Beltrán RE, Cerda-García-Rojas CM, Camacho J, Shibayama M, Tsutsumi V, Muriel P. Quercetin reverses experimental cirrhosis by immunomodulation of the proinflammatory and profibrotic processes. Fundam Clin Pharmacol. 2017 Dec;31(6):610-624. doi: 10.1111/fcp.12315. Epub 2017 Aug 31.


  • Ramos-Tovar E, Flores-Beltrán R, Galindo-Gómez S, Vera-Aguilar E, Díaz-Ruíz A, Montes S, Camacho J, Tsutsumi V y Muriel P. Stevia rebaudiana tea prevents experimental cirrosis via regulation of NF-kB, Nrf2, transforming growth factor bera, Smad7, and hepatic stellate cella activation. 2018; 1-9. Phytotherapy Research. doi: 10.1002/ptr.6197.

  • Ramos-Tovar E, Hernández-Aquino E, Casas-Grajales S, Buendia-Montaño L, Galido-Gómez S, Camacho J, Tsutsumi V, Muriel P. Stevia prevents acute and chronic liver injury induced by carbón tetrachloride by blocking oxidative stress through Nrf2 upregulation. 2018. Oxidative Medicine and Cellular Longevity. Doi. 10.1155/2018/3823426.


  • Casas-Grajales S, Alvarez-Suarez D, Ramos-Tovar E, Dayana Buendía-Montaño L, Reyes-Gordillo K, Camacho J, Tsutsumi V, Lakshman MR, Muriel P. Stevioside inhibits experimental fibrosis by down-regulating profibrotic Smad pathways and blocking hepatic stellate cell activation.

  • Basic Clin Pharmacol Toxicol. ;124(6):670-680. doi: 10.1111/bcpt.13194. Epub 2019 Jan 10. ISSN‎: ‎1742-7843

  • Casas-Grajales S, Reyes-Gordillo K, Cerda-García-Rojas CM, Tsutsumi V, Lakshman MR, Muriel P. Rebaudioside A administration prevents experimental liver fibrosis: an in vivo and in vitro study of the mechanisms of action involved. J Appl Toxicol. 2019 Aug;39(8):1118-1131. doi: 10.1002/jat.3797. Epub 2019 Mar 18. ISSN‎: ‎0260-437X (print); 1099-1263 (web)

  • Casas-Grajales S, Ramos-Tovar E, Chávez-Estrada E, Alvarez-Suarez D, Hernández-Aquino E, Reyes-Gordillo K, Cerda-García-Rojas CM, Camacho J, Tsutsumi V, Lakshman MR, Muriel P. Antioxidant and immunomodulatory activity induced by stevioside in liver damage: In vivo, in vitro and in silico assays. Life Sci. 2019 May 1;224:187-196. doi: 10.1016/j.lfs.2019.03.035. Epub 2019 Mar 16. ISSN: 1097-8135 (Print) / ISSN: 2372-613X (Online)

  • Ramos-Tovar E, Buendía-Montaño L, Galindo-Gómez S, Hernández-Aquino E, Tsutsumi V y Muriel P. Stevia prevents experimental cirrhosis by reducing hepatic myofibroblasts and modulating molecular profibrotic pathways. 2019. Hepatology Research. doi: 10.1111/hepr.13275

  • Fernández-López LA, Gil-Becerril K, Galindo-Gómez S, Estrada-García T, Ximénez C, Leon-Coria A, Moreau F, Chadee K, Tsutsumi V. Entamoeba histolytica Interaction with Enteropathogenic Escherichia coli Increases Parasite Virulence and Inflammation in Amebiasis. 2019. Infect Immun. doi: 10.1128/IAI.00279-19.


  • Cardoso-Jaime V, Maya-Maldonado K, Celestino-Montes A, Tsutsumi V, Hernández-Martínez S. Lysozyme c-1 gene is overexpressed in Anopheles albimanus pericardial cells after an immune challenge. Dev Comp Immunol. 2020 Aug 14:103830. doi: 10.1016/j.dci.2020.103830. Online

  • Bencosme, S. Tsutsumi, V. A fast method for processing biologic material for electron microscopy. Lab Invest. 23: 447-450, 1970.

  • Bencosme, S. Tsutsumi, V., Martín, JM., Akerblom, HK. Ultrastructural changes in B cells of pancreatic islets from rats with elevated levels of circulating growth hormone secreted by MtT-W15 tumor. Diabetes. 20: 15-26, 1971.

  • Àlvarez-Buylla, R., Tsutsumi, V. Adrenocortical function in hypophysectomized dogs with parotid gland transplants in direct contact with the basal hypothalamus. Acta Endocrinologica. 92(4): 710-719, 1979

  • Tsutsumi, V., Martínez-Palomo, A. Inflammatory reaction in experimental hepatic amebiasis: An ultraestructural study. Am J Pathol. 130(1): 112-119, 1988.

  • Tsutsumi, V., Mena-López, R. Anaya-Velázquez, F., Martínez-Palomo, A. Cellular bases of experimental amebic liver abscess formation. Am J Pathol. 117: 81-91, 1984.

  • Ueno, T., Inuzuka, S., Torimura, T., Sakata, R., Sakamoto, M., Gondo, K., Aoki, T. Tanikawa, K., Tsutsumi, V. Distribution of Substance P and vasoactive intestinal peptide in the human liver: light and electron immunoperoxidase methods of observation. Am J Gastroenterol. 86 (11): 1633-1637, 1991

  • Navarro-García, F., López-Revilla, R., Tsutsumi, V. Dose- and time-dependent functional and structural damage to the colon mucosa by Entamoeba histolytica trophozoite lysates. Parasitol Res. 79(6): 517-522, 1993.

  • Flores-Romo, L., Bacon, KB., Estrada-García, T., Shibayama, M., Tsutsumi, V., Martínez-Palomo, A. A fluorescence-based quantitative adhesion assay to study interactions between Entamoeba histolytica and human enterocytes interactions: Effect of proinflammatory cytokines. J Immunol Meth. 166: 243-250, 1993.

  • Flores-Romo, L., Tsutsumi, V., Estrada-García, T., Shibayama, M., Aubry, JP., Bacon, KB., Martínez-Palomo, A. CD59 (protectin) molecule, resistance to complement, and virulence of Entamoeba histolytica. Transfusion Roy Soc Trop Med Hyg. 88:116-117, 1994.

  • Campos-Rodríguez, R., Shibayama, M., Pacheco-Yépez, J., Martínez-Palomo, A., Tsutsumi, V. Passive immunization during experimental amebic liver abscess development. Parasitol Res. 81:86-88, 1995

  • Shibayama, M. Navarro-García, F., López-Revilla, R., Martínez-Palomo, A. Tsutsumi, V. In vivo and in vitro intestinal amebiasis in gerbils. Parasitol Res. 83:170-176, 1997

  • Navarro-García, F., López-Revilla, R., Vega-López, MA., Dominguez-Robles, C., Enríquez-Rincón, F., Tsutsumi, V. Intragastric immunization of rats with Entamoeba histolytica induces cecal IgE, eosiophilic infiltration, and type I hypersentivity. Clin Immunol. 82: 221-229, 1997.

  • Flores-Romo, L., Estrada-García, T., Shibayama, M., Campos-Rodríguez, R., Bacon, K., Martínez-Palomo, A., Tsutsumi, V. In vitro Entamoeba histolytica adhesion to human endothelium: a comparision using two strains of different virulence. Parasitol Res. 83:397-400, 1997.

  • Shibayama, M., Campos-Rodríguez, R., Ramírez-Rosales, A., Flores-Romo, L., Espinosa-Cantellano, M., Martínez-Palomo, A., Tsutsumi, V. Entamoeba histolytica: liver invasion and abscess production by intraperitoneal inoculation of trophozoites in hamsters, Mesocricetus auratus. Exp Parasitol. 88:20-27, 1998

  • Ventura-Juárez, J., Campos-Rodríguez, R., Rodriguez-Martínez, H., Rodríguez-Reyes, H., Martínez-Palomo, A., Tsutsumi, V. Human amebic liver abscess: expression of intercellular adhesion molecules 1 and 2 and of Von Willebrand factor in endothelial cells. Parasitol Res. 83: 510-514, 1997.

  • Velázquez, C., Shibayama, M., Aguirre-García, J., Tsutsumi, V., Calderón, J. Role of the neutrophils in the innate resistance to Entamoeba histolytica liver infection in mice. Parasite Immunol. 20: 225-262, 1998.

  • Hernández, S., Lanz, H., Rodríguez, MH., Torres, JA. Martínez-Palomo, A., Tsutsumi, V. Morphological and cytochemical characterization of female Anopheles albimanus (Diptera: Culicidae) hemocytes. J Med Entomol. 36(4):426-434, 1999.

  • Campos-Rodríguez, R, Jarillo-Luna, A., Ventura-Juárez, J., Shibayama, M., Serrano –Luna, JJ., Tsutsumi, V. Interaction of antibodies with Entamoeba histolytica trophozoites from experimental amebic liver abscess: An immunocytochemical study. Parasitol Res. 86:603-607, 2000.

  • Pacheco-Yépez, J., Campos-Rodríguez, R., Shibayama, M., Ventura-Juárez, J., Serrano-Luna, JJ., Tsutsumi, V. Entamoeba histolytica: production of nitric oxide and in situ activity of NADPH diaphorase in amebic liver abscess in hamster. Parasitol Res. 87: 49-56, 2001.

  • Ventura-Juárez, J., Campos-Rodríguez, R., Tsutsumi, V. Early interactions of Entamoeba histolytica trophozoites with parenchymal and inflammatory cells in the hamster liver: An immunocytochemical study. Can J Microbiol. 48(2):123-131, 2002.

  • Jarillo-Luna, A., Campos-Rodríguez, R., Tsutsumi, V. Entamoeba histolytica: immunohistochemical study of hepatic amoebiasis in mouse. Neutrophils and nitric oxide as possible factors of resistance. Exp Parasitol. 101(1): 40-56, 2002.

  • Shibayama, M., Serrano-Luna, JJ., Rojas-Hernández, S., Campos-Rodríguez, R., Tsutsumi, V. Interaction of secretory immunoglobilin A antibodies with Naegleria fowleri trophozoites and collagen type I. Can J Microbiol. 49(3):164-170, 2003.

  • Pacheco, J., Shibayama, M, Campos, R., Beck, DL., Houpt, E., Petri, WA., Tsutsumi V. In vitro and in vivo interaction of Entamoeba histolytica Gal/GalNAc lectin with various target cells: An immunocytochemical analysis. Parasitol International. 53(1):35-47, 2004.

  • Falcón, V., Acosta-Rivero, N., Shibayama, M., Chinea, G., Gavilondo, J., De la Rosa, MC., Menéndez, I., Gra, B., Dueñas-Carrera, S., Viña, A., García, W., González-Bravo, M., Luna-Muñoz, J., Miranda-Sánchez, M., Morales-Griollo, J., Kouri, J., Tsutsumi, V. HCV core protein localizes in the nuclei of nonparenchymal liver cells from chronically HCV-infected patients. BBRC (Biochem Biophys Res Comm). 329:1320-1328, 2005.

  • Chávez-Munguía, B., Tsutsumi, V., Martínez-Palomo, A. Entamoeba histolytica: Ultrastructure of the chromosomes and the mitotic spindle. Exp Parasitol. 114: 235-239, 2006.

  • Rivas-Santiago, B., Sada, E., Tsutsumi, V., Aguilar-León, D., León-Contreras, J., Hernández-Pando, R. B-Defensin Gene Expresión during the course of experimental tuberculosis infection. J Infect Dis. 194:697-701, 2006.

  • Tsutsumi, V., Shibayama, M., Experimental Amebiasis: A Selected Review of Some In Vivo Models. Arch Med Res. 37:210-220, 2006.

  • Shibayama, M., Dolabella, S., Silva, E., Tsutsumi, V. A Brazilian species of Entamoeba dispar (ADO) produces amoebic liver abscess in hamsters. Ann Hepatol. 6(2): Abril-Junio.117-118, 2007.

  • Tachibana, H., Yanagi, T., Akatsuka, A., Kobayashi, S., Kanbara, H., Tsutsumi, V. Isolation and characterization of potentially virulent species Entamoeba nuttalli from captive Japanese macaques. Parasitology. pgs.:1-9, 2009.

  • Olivas-Rubio, M., Hernández-Martínez, S., Talamás-Rohana, P., Tsutsumi, V., Reyes-López, PA., Rosales-Encina, JL. cDNA cloning and partial characterization of amastigote specific surface protein from Trypanosoma cruzi. Infect Genet Evol. May 27, 2009.

  • Pacheco-Yépez, J., Campos-Rodríguez, R., Rojas-Hernández, S., Serrano-Luna, JJ., Rivera-Aguilar, V., Villa-Treviño, S., Martínez-Palomo, A., Tsutsumi, V., Shibayama, M. Differential expression of surface glycoconjugates on Entamoeba histolytica and Entamoeba dispar. Parasitol Int. 58(2):171-177, 2009.

  • Nakamura, A., Ueno, T., Yagi, Y., Okuda, K., Ogata, T., Nakamura, T., Torimura, T., Iwamoto, H., Ramadoss, S., Sata, M., Tsutsumi, V., Yasuda, K., Tomiyasu, Y., Obayashi, K., Tashiro, K., Kuhara, S. Human primary cultured hepatic stellate cells can be cryopreserved. Med Mol Morphol. 43: 107-115, 2010.

  • Nakamura, T., Torimura, T., Iwamoto, H., Masuda, H., Naitou, M., Koga, H., Abe, M., Hashimoto, O., Tsutsumi, V., Ueno, T., Sata, M. Prevention of liver fibrosis and liver reconstitution af DMN-treated rat liver by transplanted EPCs. Eur J Clin Invest. 42(7):717-28, 2012.

  • Nakamura, T., Tsutsumi, V., Torimura, T., Naitou, M., Masuda, Y., Hashimoto, O., Koga, H., Abe, M., Ii., M., Kawamoto, A., Asahara, T., Ueno, T., Sata, M. Human peripheral blood CD34-positive cells enhance therapeutic regeneration of chronically injured liver in nude rats. J Cell Physiol. 227(4): 1538-1552, 2012.

  • Santana-Dolabella, S., Serrano-Luna, J., Navarro-García, F., Cerritos, R., Ximénez, C., Galván-Moroyoqui, JM., Silva, EF., Tsutsumi, V., Shibayama, M. Amoebic liver abscess production by Entamoeba dispar. Ann Hepatol. 11(1): 107-117, 2012.

  • Fernández-López LA, Gil-Becerril K, Galindo-Gómez S, Estrada-García T, Ximénez C, Leon-Coria A, Moreau F, Chadee K, Tsutsumi V. Entamoeba histolytica Interaction with Enteropathogenic Escherichia coli Increases Parasite Virulence and Inflammation in Amebiasis. 2019. Infect Immun. doi: 10.1128/IAI.00279-19.

  • Ramos-Tovar E, Flores-Beltrán RE, Galindo-Gómez S, Camacho J, Tsutsumi V, Muriel P. An aqueous extract of Stevia rebaudiana variety Morita II prevents liver damage in a rat model of cirrhosis that mimics the human disease. Ann Hepatol. 2019 May - Jun;18(3):472-479. doi: 10.1016/j.aohep.2018.10.002. Epub 2019 Apr 15. ISSN:1665-2681

  • Cardoso-Jaime V, Maya-Maldonado K, Celestino-Montes A, Tsutsumi V, Hernández-Martínez S. Lysozyme c-1 gene is overexpressed in Anopheles albimanus pericardial cells after an immune challenge. Dev Comp Immunol. 2020 Aug 14:103830. doi: 10.1016/j.dci.2020.103830. Online ahead of print.PMID: 32805306